Nonlinear optical device for micro-machining of the corneal epithelium
US12390368B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Apr 24, 2020 |
| Grant date | Aug 19, 2025 |
| Priority date | — |
| Expiry date | May 26, 2042 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61F2009/00897
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A system for creating micro-channels through superficial corneal epithelium, the system including: a femtosecond laser having a pulse energy range of 1 to 20 microjoules (μJ) and a capability of generating a laser beam having a wavelength of 700-1100 nanometers (nm) and a repetition rate of 1 kilohertz to 1 megahertz, a laser delivery system comprising a beam expander, a scanning lens having a numerical aperture (NA) of 0.05 to 0.5 and a focusing objective, and control software that controls the delivery system such that the laser beam is scanned in a pattern. The system is used to noninvasively increase corneal epithelial permeability to therapeutic agents through micron-scale channels created through the corneal epithelium by the system or to induce wound healing in a cornea in a subject following creation of micron-scale channels in the cornea.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.