Patent · US Active

Applications of butyrolactone-I in preparing medicine for preventing neuroinflammation and/or memory and cognitive disorders

US12390443B2 · kind B2 · utility

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5Claims

0Family size

Assignees

GUANDONG OCEAN UNIVERSITY · CN
SHENZHEN INSTITUTE OF GUANGDONG OCEAN UNIVERSITY · CN

Inventors

Yi Zhang · Nanjing, CN
Yingying Nie · Lo Wu, CN
Yayue Liu · Zhanjiang, CN
Xiaoxiang Ma · Dongguan, CN
Jinyue Liang · Yunfu City, CN
Yanmei Li · 流花街道, CN
Yuan Wang · Beijing, CN
Zhiyou Yang · Zhanjiang, CN
Yongping Zhang · Beijing, CN
Cai Song · Lo Wu, CN
Pengzhi Hong · Zhanjiang, CN
Zhongji Qian · Zhanjiang, CN

Key dates

Filing date	Feb 18, 2022
Grant date	Aug 19, 2025
Priority date	—
Expiry date	Jun 22, 2044

Classification

Technology area (CPC A)Human Necessities
CPC primaryA61P25/28
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Applications of butyrolactone-I in preparation of medicine for preventing aluminum-induced neuroinflammation and/or memory and cognitive disorder in zebrafish are provided. The applications have proven that at the animal level, butyrolactone-I may prevent aluminum-induced neuroinflammation and improve memory and cognitive disorder through the targets of antioxidation-inhibition of acetylcholinesterase activity-antiinflammation-regulation of intestinal flora disorder, and that butyrolactone-I may be used to prepare medicine for preventing aluminum-induced neuroinflammation and/or improving memory and cognitive disorder, thus providing a feasible scheme for preventing neurodegenerative diseases in clinical medicine.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.