Indoline-1-formamide compound, preparation method therefor, and medical use thereof
US12391666B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 9, 2019 |
| Grant date | Aug 19, 2025 |
| Priority date | — |
| Expiry date | Mar 22, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D413/14
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are a new indoline-1-carboxamide compound for regulating or inhibiting the activity of vascular endothelial growth factor receptor (VEGFR), a preparation method therefor, and the medical use thereof. Specifically, the present invention relates to a compound of general formula (I) or a pharmaceutically acceptable salt thereof, a pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt thereof, a method for treating and/or preventing VEGFR-mediated related disorders, especially tumors, using the compound or a pharmaceutically acceptable salt thereof, as well as a method for preparing the compound or a pharmaceutically acceptable salt thereof. The present invention also relates to the use of the compound or a pharmaceutically acceptable salt thereof or the pharmaceutical composition comprising the compound or a pharmaceutically acceptable salt thereof in the manufacture of a medicament for treating and/or preventing VEGFR-mediated related disorders, especially tumors. Each substituent of general formula (I) has the same definition as that in the specification.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.