Solid forms comprising (S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile and salts thereof, and compositions comprising and methods of using the same

US12391672B2 · kind B2 · utility

Assignee

• CELGENE CORPORATION · US

Inventors

• Antonio Christian Ferretti · Summit, US
• Lianfeng Huang · Jalan Pedongkelan, US
• Udaykumar Jain · Plainsboro, US
• Hon-Wah Man · Princeton, US
• Paula A. Tavares-Greco · Parsippany, US
• Wenju Wu · Hackettstown, US

Key dates

• Filing date: May 27, 2022
• Grant date: Aug 19, 2025
• Expiry date: Oct 26, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Provided herein are formulations, processes, solid forms and methods of use relating to salts of and solid forms comprising free base or salts of (S)-4-(4-(4-(((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)oxy)methyl)benzyl)piperazin-1-yl)-3-fluorobenzonitrile.