Patent · US Active

T cell receptors that bind to mixed lineage leukemia (MLL)-specific phosphopeptides and methods of use thereof

US12391741B2 · kind B2 · utility

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2References
20Claims
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Assignee

Inventors

Key dates

Filing dateJun 23, 2023
Grant dateAug 19, 2025
Priority date—
Expiry dateJun 23, 2043

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07K2317/565
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Provided are TCRs (e.g., TCRs that bind to MLL, e.g., TCRs that bind to an MLL phosphopeptide, e.g., TCRs that bind to an MLL phosphopeptide/MHC complex), cells and pharmaceutical compositions comprising these TCRs, nucleic acids encoding these TCRs, expression vectors and host cells for making these TCRs, and methods of treating a subject using these TCRs.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.