Compositions and methods comprising antibodies that bind to covalent peptide conjugates

US12391770B2 · kind B2 · utility

Assignee

• NEW YORK UNIVERSITY · US

Inventors

• Shohei Koide · Nagoya, JP
• Benjamin G. Neel · Wayland, US
• Carmine FEDELE · New York, US
• Kai Wen Teng · Queens, US
• Akiko Koide · New York, US
• Takamitsu Hattori · West New York, US
• Lorenzo MASO · New York, US

Key dates

• Filing date: Feb 23, 2024
• Grant date: Aug 19, 2025
• Expiry date: Feb 23, 2044

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/73
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are compositions and methods that include binding partners that bind with specificity to target sites on proteins or peptides that comprise a covalently attached molecule. The binding partners are provided as antibodies and antibody derivatives that specifically bind to proteins and peptides that have been covalently modified by attachment of a molecule, such as a drug. The binding partners can bind with specificity to covalently modified peptides when presented in the context of a major histocompatibility complex (MHC). Uses of the compositions and methods for prophylaxis or therapy of disorders are also provided.