RNA-guided DNA nucleases and uses thereof
US12391932B2 · kind B2 · utility
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38References
35Claims
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Assignee
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Key dates
| Filing date | Jun 5, 2023 |
| Grant date | Aug 19, 2025 |
| Priority date | — |
| Expiry date | Jun 5, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/80
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Provided herein are systems, methods, and compositions for the modification of target DNA sequences. More particularly, systems, methods, and compositions for cleaving a target DNA in eukaryotic cells with a guide RNA capable of hybridizing with a target sequence and an RNA-guided DNA nuclease are provided. Also provided are vectors and vector systems which encode one or more components of a CRISPR complex, as well as methods for the design and use of such vectors. Also provided are methods for identifying and validating novel CRISPR systems.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.