Systems and methods for ex-vivo organ care and for using lactate as an indication of donor organ status
US12396454B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | May 7, 2024 |
| Grant date | Aug 26, 2025 |
| Priority date | — |
| Expiry date | May 7, 2044 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01N1/148
- WIPO fieldBasic materials chemistry
- WIPO sectorChemistry
Abstract
The disclosure provides, in various embodiments, systems, devices and methods relating to ex-vivo organ care. In certain embodiments, the disclosure relates to maintaining an organ ex-vivo at near-physiologic conditions. The present application describes, for example, a method for using lactate measurement in the arterial and the venous blood lines of the Organ Care System Heart perfusion device to evaluate, for example, the: 1) overall perfusion status of an isolated heart; 2) metabolic status of an isolated heart; and 3) overall vascular patency of an isolated donor heart. This aspect of the present disclosure may use, for example, the property of myocardial cell's unique ability to produce/generate lactate when they are starved for oxygen and metabolize/utilize lactate for energy production when they are well perfused with oxygen.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.