Method for direct reprogramming of urine cells into neural stem cells using synthetic MRNA
US12397020B2 · kind B2 · utility
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4Claims
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Key dates
| Filing date | Aug 28, 2019 |
| Grant date | Aug 26, 2025 |
| Priority date | — |
| Expiry date | Jul 3, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/90
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A method for inducing reprogramming of neural stem cells from urine cells by introducing mRNAs of reprogramming factors Oct4, Sox2, Klf4, and Glis1 is disclosed. A composition for the prevention or treatment of neurological damage diseases with the neural stem cells induced by the method as an active ingredient is disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.