Microcapsule-based vaccine

US12397052B2 · kind B2 · utility

Assignee

• INSTITUTE OF PROCESS ENGINEERING, CHINESE ACADEMY OF SCIENCES · CN

Inventors

• Guanghui Ma · Beijing, CN
• Wei Wei · Galveston, US
• Xiaobo XI · Beijing, CN
• Tong Ye · Beijing, CN
• Xiangming NA · Beijing, CN
• Shuang Qing · Beijing, CN

Key dates

• Filing date: Aug 16, 2019
• Grant date: Aug 26, 2025
• Expiry date: Jan 6, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N2730/10134
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A vaccine comprising antigen and a matrix of biodegradable polymer blend, wherein the polymer blend comprises hydrophobic polymer and amphiphilic block copolymer, and the vaccine exists in form of microcapsules that comprise a multi-cavity structure inside, and has an average particle diameter of preferably 10-100 μm and more preferably 30-60 μm, and is prepared by means of the following method: making porous microspheres from the polymer blend, then mixing the porous microspheres with antigen-containing solution, and then sealing openings of porous microspheres that have been loaded with the antigen-containing solution to form an opening-sealed microcapsule loaded with the antigen.