Collections of peptides, peptide agents, and methods of use thereof

US12398178B2 · kind B2 · utility

Assignee

• Parabilis Medicines, Inc. · US

Inventors

• John Hanney McGee · Palo Alto, US
• Ty Matthew Thomson · Arlington, US
• Sebastian Christof Theodor Wahl · Bonn, DE
• Gregory L. Verdine · Boston, US
• Raheleh Rezaei Araghi · Brookline, US
• Yue-Mei Zhang · Wellesley, US
• Mark J. Mulvihill · Melville, US

Key dates

• Filing date: Aug 20, 2019
• Grant date: Aug 26, 2025
• Expiry date: Nov 27, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K7/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure provides powerful technologies for the development, production, characterization, and/or use of stapled peptide compositions. Among other things, the present disclosure provides strategies for defining amino acid sequences particularly amenable or useful for stapling, as well as technologies, reagents, and systems for developing, producing, characterizing, and/or using stapled peptides having such amino acid sequences.