Methods and compositions for delivery of agents across the blood-brain barrier
US12398181B2 · kind B2 · utility
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12References
11Claims
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Key dates
| Filing date | Jul 11, 2019 |
| Grant date | Aug 26, 2025 |
| Priority date | — |
| Expiry date | Mar 11, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K14/005
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention is based on the development of artificial targeting sequences that enhance permeation of agents into cells and across the blood brain barrier, compositions comprising the sequences, and methods of use thereof. Provided herein is an AAV comprising a capsid protein comprising a targeting sequence and a transgene, preferably a therapeutic or diagnostic transgene. Further, provided herein are methods of delivering a transgene to a cell, the method comprising contacting the cell with an AAV or fusion protein described herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.