Enhanced immune effector cells and use thereof
US12398373B2 · kind B2 · utility
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26Claims
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Key dates
| Filing date | Dec 21, 2018 |
| Grant date | Aug 26, 2025 |
| Priority date | — |
| Expiry date | Nov 4, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N5/0696
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided are methods and compositions for obtaining functionally enhanced derivative effector cells obtained from directed differentiation of genomically engineered iPSCs. The derivative cells provided herein have stable and functional genome editing that delivers improved or enhanced therapeutic effects. Also provided are therapeutic compositions and the used thereof comprising the functionally enhanced derivative effector cells alone, or with antibodies or checkpoint inhibitors in combination therapies.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.