Enzymatic method for the production of L-glufosinate P-esters

US12398410B2 · kind B2 · utility

Assignee

• Evonik Operations GmbH · DE

Inventors

• Ludger Lautenschütz · Hanau, DE
• Steffen Oßwald · Nidderau, DE
• Markus Pötter · Shanghai, CN
• Jakob Muller · Haltern am See, DE

Key dates

• Filing date: Mar 14, 2022
• Grant date: Aug 26, 2025
• Expiry date: Mar 14, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12P13/04
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

A first enzymatic method for the production of an L-glufosinate P-ester includes reacting an L-glufosinate P-ester carbamoylate to give the corresponding L-glufosinate P-ester in the presence of a carbamoylase as a catalyzer. A second enzymatic method includes the enantioselective production of an L-glufosinate P-ester from a mixture MIIIA of L- and D-glufosinate P-ester hydantoins. The L-glufosinate P-ester obtained in the two methods may be saponified to give L-glufosinate.