Benzimidazole thiophene derivative compounds inducing selective degradation of PLK1
US12403198B2 · kind B2 · utility
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Key dates
| Filing date | Mar 27, 2021 |
| Grant date | Sep 2, 2025 |
| Priority date | — |
| Expiry date | Sep 20, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D519/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides novel compounds that induce selective polo-like kinase 1 (PLK1) degradation. Specifically, the present invention provides a bifunctional compound in which a PLK1 binding moiety and an E3 ubiquitin ligase-binding moiety are linked by a chemical linker. The present invention provides the compound, a method for preparing the same, and the use thereof. The compounds may be effectively utilized for preventing or treating PLK1 related diseases.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.