Patent · US Active

Bivalent bispecific antibody and preparation method thereof, coding gene, host cell and composition

US12404326B2 · kind B2 · utility

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8Claims

0Family size

Assignee

CHANGCHUN GENESCIENCE PHARMACEUTICAL CO., LTD. · CN

Inventors

Xiao-fan Feng · Camas, US
Lei Jin · Unionville, US
Tao Wang · Farmington, US
Hongrui Guo · Jilin, CN
Shuang LIU · Xiamen, CN
Yuheng CHEN · Deans, US
Ning HAN · Jilin, CN
Yangqiu Liang · Changchun, CN

Key dates

Filing date	Dec 26, 2019
Grant date	Sep 2, 2025
Priority date	—
Expiry date	Jan 1, 2043

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2317/92
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Provided are a bivalent bispecific antibody and a preparation method thereof, a coding gene, a host cell and a composition. The bivalent bispecific antibody comprises: a) a single-chain variable fragment scFv, a flexible peptide, a heavy chain IgG1 constant region CH1 and a hinge region partial sequence of the antibody that specifically binds to a first antigen, and b) a single-chain variable fragment scFv, and a light chain constant region CL, that is, scFv1-CL or CL-scFv1, of the antibody that specifically binds to a second antigen; or comprises: c) a light chain and a heavy chain of the antibody that specifically binds to the first antigen, and d) a light chain and a heavy chain of the antibody that specifically binds to the second antigen.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.