Facing and quality control in microtomy

US12405194B2 · kind B2 · utility

Assignee

• Clarapath, Inc. · US

Inventors

• Partha P. Mitra · New York, US
• Charles R. Cantor · Del Mar, US
• Baris Yagci · Montclair, US
• David Kleinfeld · New York, US
• Cong Zhang · Shandong, CN
• Steven W. Smith · Columbus, US

Key dates

• Filing date: Feb 22, 2021
• Grant date: Sep 2, 2025
• Expiry date: Jun 1, 2042

Classification

• Technology area (CPC G): Physics
• CPC primary: G06T2207/30024
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

The present disclosure relates to systems and methods for facing a tissue block. In some embodiments, a method is provided for facing a tissue block that includes imaging a tissue block to generate imaging data of the tissue block, the tissue block comprising a tissue sample embedded in an embedding material, estimating, based on the imaging data, a depth profile of the tissue block, wherein the depth profile comprises a thickness of the embedding material to be removed to expose the tissue sample to a pre-determined criteria, and removing the thickness of the embedding material to expose the tissue to the pre-determined criteria.