Magnetic resonance imaging of glycogen and other polysaccharides by magnetic coupling with water
US12405333B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Nov 19, 2021 |
| Grant date | Sep 2, 2025 |
| Priority date | — |
| Expiry date | May 25, 2042 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02A90/30
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Some embodiments provide a method for magnetic resonance imaging of polysaccharide molecules, that includes providing a magnetic field that is sufficiently homogeneous over an imaging volume, generating a spatial encoding in the magnetic field, and acquiring one or more water proton signal intensity measurements at each of multiple voxels within the imaging volume. The signal intensity measurements are acquired at one or more irradiation frequencies at lower parts-per-million (ppm) than a baseline frequency associated with free water protons. The method includes generating, based on the water proton signal intensity measurements in each voxel, a water proton signal intensity map of the relayed Nuclear Overhauser Effect (rNOE) exchange process of aliphatic protons in the polysaccharide molecules to free water protons in the imaging volume, and generating, using a calibration of the water proton signal intensity measurements for the rNOE exchange process, a concentration map of the polysaccharide molecules in the imaging volume.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.