Modification of plant messenger packs with charged lipids

US12409137B2 · kind B2 · utility

Assignee

• Flagship Pioneering Innovations VI, LLC · US

Inventors

• Maria Helena Christine VAN ROOIJEN · Cambridge, US
• Hok Hei Tam · Newton, US
• Maier Steve Avendaño Amado · Cambridge, US
• Barry Andrew Martin · Boston, US
• Ignacio Martinez · Lexington, US
• Piotr S. Kowalski · Cork, IE
• Nataliya Vladimirovna NUKOLOVA · Cambridge, US
• John Patrick CASEY, JR. · Boston, US
• Siddharth PATEL · Corvallis, US
• Roman Lvovitch Bogorad · Cambridge, US

Key dates

• Filing date: Aug 24, 2020
• Grant date: Sep 9, 2025
• Expiry date: May 19, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12N15/88
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein are compositions including a plurality of plant messenger packs, (e.g., including a plant extracellular vesicle (EV), or segment, portion, or extract thereof), that are modified to have enhanced cell uptake (e.g., animal plant cell uptake, bacterial cell uptake, or fungal cell uptake), e.g., for use in a variety of agricultural or therapeutic methods.