Synthesizing drug-organic-acid-anhydride conjugates without using coupling reagent
US12409229B2 · kind B2 · utility
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Key dates
| Filing date | Apr 12, 2021 |
| Grant date | Sep 9, 2025 |
| Priority date | — |
| Expiry date | Jul 28, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07D325/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Synthesizing a drug-organic-acid-anhydride conjugate using docetaxel as a drug, including: mixing aconitic anhydride with a chlorinating reagent to produce a first mixture; dissolving the first mixture in an organic solvent to produce a dissolved mixture; stirring the dissolved mixture; evaporating the organic solvent from the dissolved mixture to produce a second mixture; washing the second mixture with an impurity remover to remove impurities and to produce an aconitic anhydride chloride solution; and mixing the docetaxel with the aconitic anhydride chloride solution to produce the drug-organic-acid-anhydride conjugate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.