Insulin analogs

US12410228B2 · kind B2 · utility

Assignees

• University of Utah Research Foundation · US
• THE WALTER AND ELIZA HALL INSTITUTE OF MEDICAL RESEARCH · AU

Inventors

• John Gerbrandt Tasman Menting · Melbourne, AU
• Brian John Smith · Melbourne, AU
• Danny Hung-Chieh Chou · Salt Lake City, US
• Helena Safavi-Hemami · Salt Lake City, US
• Michael Colin Lawrence · Mona Vale, AU
• Baldomero M. Olivera · Salt Lake City, US

Key dates

• Filing date: Jan 4, 2022
• Grant date: Sep 9, 2025
• Expiry date: Mar 27, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2299/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to insulin analogs, particularly insulin analogs having shortened B chains. The present invention also relates to the crystal structure of insulin from the venom of cone snails and to methods of using the crystal and related structural information to screen for and design insulin analogs that interact with or modulate the insulin receptor. The present invention also relates to therapeutic and prophylactic methods using insulin analogs.