Monoclonal antibodies against JC virus

US12410238B2 · kind B2 · utility

Assignee

• ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · US

Inventors

• Thomas M. Moran · New York, US
• Thomas Kraus · Palmdale, US
• J. Andrew Duty · New York, US
• Domenico Tortorella · New York, US

Key dates

• Filing date: Jun 19, 2020
• Grant date: Sep 9, 2025
• Expiry date: Sep 13, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Provided herein are monoclonal antibodies and antigen-binding fragments thereof that bind to the John Cunningham virus. Also provided are pharmaceutical compositions comprising the monoclonal antibodies and antigen-binding fragments thereof, as well as methods of using such monoclonal antibodies and antigen-binding fragments thereof, including methods for the treatment and/or prevention of JCV infections and/or progressive multifocal leukoencephalopathy.