Antibodies capable of binding to OX40, variants thereof and uses thereof
US12410258B2 · kind B2 · utility
0Cited by
21References
23Claims
0Family size
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Key dates
| Filing date | May 10, 2024 |
| Grant date | Sep 9, 2025 |
| Priority date | — |
| Expiry date | May 10, 2044 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/92
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention relates to antibodies capable of binding to human OX40 and to variants thereof comprising a modified Fc region comprising at least one mutation that enhances the Fc-Fc interaction of the antibody and at least one mutation that reduces the Fc effector functions of the antibody. The invention further provides pharmaceutical compositions comprising the antibodies and use of the antibodies for therapeutic and diagnostic procedures, in particular in cancer therapy.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.