Systems and methods relating to medical applications of inverse thermosensitive polymer foam formulations

US12410293B2 · kind B2 · utility

Assignee

• Critical Innovations, LLC · US

Inventors

• Ross I. Donaldson · Inglewood, US
• Jonathan Armstrong · Los Angeles, US
• Oliver Buchanan · Lawndale, US
• John Cambridge · Los Angeles, US
• Timothy C. Fisher · Los Angeles, US
• Nely Cristerna · Lawndale, US

Key dates

• Filing date: Oct 12, 2023
• Grant date: Sep 9, 2025
• Expiry date: Mar 13, 2044

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C08J2371/02
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Disclosed herein is a pressurized therapeutic composition configured to be stored in a valved container designed to maintain an inverse thermosensitive polymer foam composition under pressure and dispense the composition upon opening the valve thereof. After the composition is dispensed from the container the evaporation of an expanding component (e.g., compressed gas or volatile liquid) can cause the inverse thermosensitive polymer solution to foam. The reduced pressure produced from dispensing the inverse thermosensitive polymer solution can reduce its temperature so as to facilitate distribution in a more liquid foam form. The inverse thermosensitive polymer solution can undergo a reverse phase change from a liquid to a gel upon warming (e.g., once dispensed onto or into a body part).