Generation of functional neutrophils and macrophages from induced pluripotent stem cells in chemically defined conditions using transient expression of ETV2
US12410401B2 · kind B2 · utility
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Key dates
| Filing date | Jun 5, 2020 |
| Grant date | Sep 9, 2025 |
| Priority date | — |
| Expiry date | Mar 7, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2510/00
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention provides methods of producing in vitro derived neutrophils or macrophages in xenogen- and serum-free conditions from pluripotent stem cells and in vitro derived populations of neutrophils and macrophages. Methods of treatment using in vitro derived neutrophils or macrophages are also contemplated.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.