RNA-guided transcriptional regulation and methods of using the same for the treatment of back pain
US12410428B2 · kind B2 · utility
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10Claims
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Key dates
| Filing date | Oct 18, 2019 |
| Grant date | Sep 9, 2025 |
| Priority date | — |
| Expiry date | Oct 7, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2800/80
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein are compositions and methods for treatment and prevention of low back pain. The compositions include vectors comprising nucleotide sequences encoding one or more CRISPR-Cas system guide RNAs and a RNA-directed nuclease. The methods include modulating expression of one or more genes in a cell using the compositions, introducing a CRISPR-Cas system into a cell comprising one or more vectors comprising the compositions, including site-specific DNA cleavage in a cell, and treating a subject having lower back pain, and lower back pain caused by degenerative disc disease using the compositions disclosed herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.