Method for cold plasma induced cell death in breast cancer cells by 8-oxoG modification and degradation of histone mRNA
US12410484B2 · kind B2 · utility
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| Filing date | Jul 5, 2022 |
| Grant date | Sep 9, 2025 |
| Priority date | — |
| Expiry date | Jul 5, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06V20/69
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method for inducing cell death in breast cancer regardless of subtyping through histone mRNA oxidation and degradation during the early S-phase of the cell cycle. A method for monitoring levels of oxidized histone mRNA in breast cancer cells, comprising the steps of isolating histone mRNA from breast cancer cells, incubating the histone mRNA with a peptide according to SEQ ID NO: 1 and determining the levels of oxidized histone mRNA by measuring the fluorescence intensity.
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