Characterizing intra-site tumor heterogeneity
US12412272B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Nov 24, 2020 |
| Grant date | Sep 9, 2025 |
| Priority date | — |
| Expiry date | Jul 5, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG06T2207/30096
- WIPO fieldMedical technology
- WIPO sectorInstruments
Abstract
A method and a system for measuring intra-site heterogeneity in a tumor using magnetic resonance imaging (MRI). The method includes acquiring magnetic resonance (MR) images using MRI modality; segmenting tumor sites in the MR images; dividing each of the tumor sites into a plurality of sub-regions; deriving image biomarkers from each voxel or pixel in the plurality of sub-regions; classifying each voxel or pixel in the plurality of sub-regions into genotypes or molecular subtypes based on the extracted image biomarkers and a classifier model including associations between image biomarkers and genotypes or molecule subtypes; creating a distribution of genotypes or molecular subtypes in the each of the plurality of sub-regions based on classifications of voxels or pixels; generating spatial information of genotypes or molecular subtypes in the tumor sites based on the distribution; and measuring intra-site heterogeneity in the tumor sites.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.