IgE epitope-like peptides and uses thereof

US12415839B2 · kind B2 · utility

Assignees

• Univerza v Ljubjani · SI
• University Clinic of Respiratory and Allergic Diseases · SI

Inventors

• Mojca Lunder · Ljubljana, SI
• Borut Strukelj · Ljubljana, SI
• Peter Korošec · Ljubljana, SI
• Ana Koren · Ljubljana, SI
• Jernej Luzar · Dobrava pri Črnučah, SI
• Abida Zahirović

Key dates

• Filing date: May 29, 2018
• Grant date: Sep 16, 2025
• Expiry date: Jan 20, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K2039/577
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to IgE epitope-like peptides which have ability to bind to allergen specific IgE paratopes. Said allergen specific IgEs are bound to effector cells of allergic patients. The IgE epitope-like peptides of the invention cover the paratopes of said IgE bound on effector cells, prevent biding of causative allergen on said IgE on effector cells, and thereby prevent degranulation and secretion of mediators of allergic inflammation from effector cells, after contact with the causative allergen. The present invention relates to the methods of using such IgE epitope-like peptides for therapy of allergic reaction. Said allergic reaction is caused by exposure to the causative allergen.