Production method for neuron-like cells
US12415986B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 5, 2019 |
| Grant date | Sep 16, 2025 |
| Priority date | — |
| Expiry date | Oct 10, 2041 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2506/1307
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
It is a main object of the present invention to provide a process for producing a neuron-like cell from a somatic cell, a neuron-like cell obtained thereby, and a composition comprising a combination of chemical substances that can be used for said process without performing artificial gene transfer.The invention can include, for example, a process for producing neuron-like cells, characterized by comprising a step of culturing somatic cells in the presence of two kinds of inhibitors, i.e., a TGF-β inhibitor and a BMP inhibitor, as well as any three or more selected from the group consisting of four kinds, i.e., a cAMP inducer, a GSK3 inhibitor, an Erk-inhibitor, and a p53-inhibitor, wherein the TGF-β inhibitor is a selective ALK5 inhibitor, and a neuron-like cell obtained by said process.The neuron-like cells obtained according to the present invention are useful in regenerative medicine and the like.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.