Adeno-associated virus (AAV) vectors, AAV vectors having reduced capsid deamidation and uses therefor
US12416016B2 · kind B2 · utility
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25Claims
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Key dates
| Filing date | Feb 27, 2019 |
| Grant date | Sep 16, 2025 |
| Priority date | — |
| Expiry date | Apr 23, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14143
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A recombinant adeno-associated virus (rAAV) vector comprising an AAV capsid having a heterogeneous population of vp1 proteins, a heterogeneous population of vp2 protein and a heterogeneous population of vp3 proteins. The capsid contains modified amino acids as compared to the encoded VP1 amino acid sequence, the capsid containing highly deamidated asparagine residues at asparagine-glycine pair, and further comprising multiple other, less deamidated asparagine and optionally glutamine residues.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.