Patent · US Active

T4 DNA ligase variants with increased ligation efficiency

US12416044B2 · kind B2 · utility

0Cited by

2References

10Claims

0Family size

Assignee

AbClonal Science, Inc. · US

Inventors

Zhenyu Zhu · Lynnfield, US
Aine Quimby · Newburyport, US
Dapeng Sun · Lexington, US
Alicia DiCicco · Salem, US

Key dates

Filing date	Mar 21, 2022
Grant date	Sep 16, 2025
Priority date	—
Expiry date	Sep 1, 2042

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Y605/01001
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The invention includes a mutant T4 DNA ligase or a biologically active fragment thereof, which has greater activity than wild type T4 DNA ligase. The mutant T4 DNA ligase, or the biologically active fragment, has one or more substitutions differing from the wild type, as described more fully in the Summary.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.