Use of vapor deposition coated flow paths for improved chromatography of metal interacting analytes

US12416607B2 · kind B2 · utility

Assignee

• Waters Technologies Corporation · US

Inventors

• Matthew A. Lauber · 47th Avenue Court, US
• Mathew H. DeLano · Needham, US
• Scott A. McCall · Smithfield, US
• Jonathan Belanger · Northbridge, US
• Theodore A. Dourdeville · Falmouth, US
• Kerri Smith · Marlborough, US
• Paul Rainville · Princeton, US
• Dimple Shah · Medway, US
• Stephen J. Shiner · Holden, US
• Catalin Doneanu · Franklin, US
• Michael Donegan · Williamstown, US

Key dates

• Filing date: Jun 7, 2023
• Grant date: Sep 16, 2025
• Expiry date: Aug 4, 2043

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2030/567
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A device for separating analytes is disclosed. The device has a sample injector, sample injection needle, sample reservoir container in communication with the sample injector, chromatography column downstream of the sample injector, and fluid conduits connecting the sample injector and the column. The interior surfaces of the fluid conduits, sample injector, sample reservoir container, and column form a flow path having wetted surfaces. A portion of the wetted surfaces of the flow path are coated with an alkylsilyl coating that is inert to at least one of the analytes. The alkylsilyl coating has the Formula I: R1, R2, R3, R4, R5, and R6 are each independently selected from (C1-C6)alkoxy, —NH(C1-C6)alkyl, —N((C1-C6)alkyl)2, OH, ORA, and halo. RA represents a point of attachment to the interior surfaces of the fluidic system. At least one of R1, R2, R3, R4, R5, and R6 is ORA. X is (C1-C20)alkyl, —O[(CH2)2O]1-20—, —(C1-C10)[NH(CO)NH(C1-C10)]1-20—, or —(C1-C10)[alkylphenyl(C1-C10)alkyl]1-20-.