System and apparatus for simplified diffusion imaging fitting using a rotational invariant dictionary

US12416697B2 · kind B2 · utility

Assignee

• NEW YORK SOCIETY FOR THE RELIEF OF THE RUPTURED AND CRIPPLED, MAINTAINING THE HOSPITAL FOR SPECIAL SURGERY · US

Inventors

• Darryl B. Sneag · Plainview, US
• Ek Tsoon Tan · Niskayuna, US

Key dates

• Filing date: Dec 14, 2021
• Grant date: Sep 16, 2025
• Expiry date: May 23, 2042

Classification

• Technology area (CPC G): Physics
• CPC primary: G01R33/5608
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

A computer-implemented method includes: generating a set of simulated diffusion signals based on a corresponding set of diffusion sampling parameters and a corresponding set of micro structural model parameters, wherein the diffusion sample parameters correspond to magnetic resonance (MR) parameters, and wherein the microstructural model parameters characterizing a microscopic diffusion with a spatial orientation; processing the set of simulated diffusion signals based on the corresponding set of diffusion sampling parameters to generate a first set of output metrics, wherein the first set of output metrics are associated with the spatial orientation; consolidating multiple sets of output metrics into a dictionary, wherein each set of the multiple sets of output metrics are generated by processing a corresponding set of simulated diffusion signals and associated with a corresponding spatial orientation; applying the dictionary to a set of acquired diffusion MR signals; and generating at least one macroscopic diffusion feature that is orientation invariant.