Ion channel prosthetic compositions comprising lipid-coated crystals of amphotericin B
US12419899B2 · kind B2 · utility
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26Claims
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Key dates
| Filing date | Sep 20, 2024 |
| Grant date | Sep 23, 2025 |
| Priority date | — |
| Expiry date | Sep 20, 2044 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K31/575
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed are pharmaceutical compositions, comprising: (i) amphotericin B or a pharmaceutically acceptable salt or hydrate thereof; (ii) cholesterol; (iii) phospholipids, comprising hydrogenated soy phosphatidylcholine and distearoylphosphatidylglycerol; and (iv) calcium chloride (CaCl2)). Also disclosed are methods of using the pharmaceutical compositions for treating a disease or disorder (e.g., cystic fibrosis), increasing the pH of airway surface liquid, increasing bicarbonate secretion into airway surface liquid, and increasing a subject's forced expiratory volume in one second.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.