Diet controlled expression of a nucleic acid encoding a pro-apoptotic protein
US12419971B2 · kind B2 · utility
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Key dates
| Filing date | Dec 26, 2019 |
| Grant date | Sep 23, 2025 |
| Priority date | — |
| Expiry date | Apr 23, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/30
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A nucleic acid for the controlled expression of a nucleic acid encoding a pro-apoptotic protein in an individual, including: a regulatory polynucleotide including a minimal promoter and at least one AARE (amino acid response element) nucleic acid, the regulatory polynucleotide being activated in an individual upon consumption of a diet deficient in at least one essential amino acid; and a nucleic acid encoding a pro-apoptotic protein, which is placed under the control of the regulatory polynucleotide.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.