Biosensor tattoos and uses therefor for biomarker monitoring
US12420073B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Dec 23, 2020 |
| Grant date | Sep 23, 2025 |
| Priority date | — |
| Expiry date | May 24, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2830/002
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Provided herein are devices and methods used to produce tattoo biosensors that are based on spatially controlled intracutaneous gene delivery of optical reporters driven by specific transcription factor pathways for a given cytokine or other analyte. The biosensors can be specific to a given analyte, or more generically represent the convergence of several cytokines into commonly shared intracellular transcription factor pathways. These biosensors can be delivered as an array in order to monitor multiple cytokines. Biosensor redeployment can enable chronic monitoring from months to years. The tattooed biosensor array of the present invention includes endogenous reporter cells, naturally tuned to each patient's own biology and can be used to reliably measure the state of a patient in real-time.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.