Bicyclic-substituted glutarimide cereblon binders

US12421220B2 · kind B2 · utility

Assignee

• C4 THERAPEUTICS, INC.

Inventors

• Christopher G. Nasveschuk · Stoneham, US
• Kiel Lazarski · Cambridge, US
• Yanke Liang · Belmont, US
• Alexander Hird · Belmont, US
• Ning Yin · Lexington, US
• Andrew C. Good · Wallingford, US
• Hongwei Huang · Bedford, US
• Scott Joseph Eron · Waltham, US
• Gesine Kerstin Veits · Somerville, US

Key dates

• Filing date: Dec 6, 2024
• Grant date: Sep 23, 2025
• Expiry date: Dec 6, 2044

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D498/04
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention provides Degron compounds which bind to cereblon which is a component of the E3 ubiquitin ligase. The Degrons provided herein can be used to modulate the activity of cereblon either alone or as covalently linked to a Tail. Alternatively, the Degron can be linked to a Targeting Ligand which binds to a Target Protein for protein degradation.