Pharmaceutical composition for treating or preventing aging or age-related diseases
US12427143B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jul 23, 2021 |
| Grant date | Sep 30, 2025 |
| Priority date | — |
| Expiry date | Jan 17, 2044 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61Q19/08
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
HTS screening was performed regarding cell proliferation, one of symptoms of senescence. As a result, KB1541, which was the most effective on cell proliferation, was earned. The present invention described how the compound regulates cell proliferation and senescence. The present invention uncovered what proteins interacted with the compound using streptavidin-magnetic beads after treating with biotin-connected KB1541. Consequently, it was identified that mitochondrial proteins interacted with the compound. In ATP assay, electron microscope and IP assay, the inventors identified that the compound regulated mitochondrial proteins and thereby increased ATP production as well as recovered senescence.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.