Ultrasound arrays for enhanced sonodynamic therapy for treating cancer
US12427345B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jun 28, 2023 |
| Grant date | Sep 30, 2025 |
| Priority date | — |
| Expiry date | Jun 28, 2043 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB06B2201/76
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Ultrasound transducer element arrays using acoustic ensonification drive patterns via a patient interface for sonosensitizer activation in sonodynamic therapy. Incoherent acoustic field generation varying phase, frequencies, and/or amplitude via controlled delivery of low intensity planar acoustic waves. Method includes generating a first and a second signal to generate respective acoustic ensonification drive patterns with phase, frequency, and amplitude and generating at least one relative phase, frequency or amplitude difference to generate a third incoherent acoustic ensonification pattern to activate a sonosensitizer. Calibration and complementary therapy procedures to improve cell susceptibility of cells to sonodynamic therapy are disclosed.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.