Methods for purifying isavuconazonium sulfate
US12428414B2 · kind B2 · utility
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29Claims
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Key dates
| Filing date | Jul 29, 2019 |
| Grant date | Sep 30, 2025 |
| Priority date | — |
| Expiry date | Dec 28, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07B2200/13
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The invention provides methods for purifying isavuconazonium sulfate comprising the steps of —(a) providing a mixture comprising the sulfate salt of the compound of formula (I) and an aliphatic alcohol, wherein the pH of the mixture is in the range of about pH 1 to about pH 6; —(b) allowing a first portion of the sulfate salt of the compound of formula (I) to crystalize from the mixture; and —(c) adding an aprotic organic solvent to the mixture and allowing an additional portion of the sulfate salt of the compound of formula (I) to precipitate from the mixture.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.