Chimeric antigen receptors that bind to prostate specific membrane antigen

US12428492B2 · kind B2 · utility

Assignee

• Albert-Ludwigs-Universitaet Freiburg · DE

Inventors

• Toni CATHOMEN · Freiburg (Elbe), DE
• Philipp Wolf · Gundelfingen, DE
• Jamal ALZUBI · Freiburg (Elbe), DE
• Susanne SCHULTZE-SEEMANN · Merzhausen, DE
• Irina KUCKUCK · Freiburg (Elbe), DE

Key dates

• Filing date: Dec 14, 2020
• Grant date: Sep 30, 2025
• Expiry date: Dec 14, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/33
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention relates to a novel chimeric antigen receptor (CAR) comprising an antigen-binding fragment which binds specifically to PSMA antigen, and a method of manufacturing high-quality CAR T cell products by transfection and/or transduction of T cells therewith, which allows to effectively treat tumors in vivo alone or in combination with pharmaceutical drugs, such chemotherapies, biopharmaceutical drugs, such as antibodies, or small-molecule drugs, such as protein kinase inhibitors.