Compositions comprising peptides that block transmission of orthotospoviruses
US12428648B2 · kind B2 · utility
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20Claims
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Key dates
| Filing date | Mar 6, 2023 |
| Grant date | Sep 30, 2025 |
| Priority date | — |
| Expiry date | Jul 21, 2043 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2760/12022
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
Orthotospovirus virions travel through the thrips foregut and enter midgut epithelial cells through the interaction between virus glycoproteins and cellular receptors with several protein motifs thought to be involved in the interaction. Single, double and triple mutant polypeptides in the soybean vein necrosis virus (SVNV)/Neohydatothrips variabilis system are provided herein and several are shown to block viral transmission from the thrips to the soybean plants. Methods for inhibiting viral transmission using these polypeptides or constructs comprising polynucleotides encoding peptides are also provided herein.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.