Compositions and methods related to kethoxal derivatives
US12428666B2 · kind B2 · utility
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15Claims
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Key dates
| Filing date | May 8, 2019 |
| Grant date | Sep 30, 2025 |
| Priority date | — |
| Expiry date | Jul 25, 2042 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12Q2565/518
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
Embodiments are directed to N3-kethoxal reagents and derivatives thereof, and related methods that allow fast and reversible labeling of single-stranded nucleic acids in live cells. By way of example, one aspect is directed to a process for reversible labeling of single-stranded guanine bases in live cells, which results in an effective in vivo method for transcriptome-wide RNA secondary structure mapping and RNA G-quadruplex prediction.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.