Novel heptapeptides having gastrin activity

US3931141A · kind A · utility

Assignee

• Hoechst GmbH · DE

Inventors

• Hans Wissmann · Bad Soden am Taunus, DE
• Rolf Geiger · Frankfurt am Main, DE
• Rudolf Schleyerbach · Hofheim, DE

Key dates

• Filing date: Nov 15, 1973
• Grant date: Jan 6, 1976
• Expiry date: Nov 15, 1993

Classification

• Technology area (CPC Y): Emerging Cross-Sectional Technologies
• CPC primary: Y02P20/55
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Heptapeptides of the general formula EQU HOOC--(CH.sub.2).sub.3 --CO--Ala--Tyr--Gly--Trp--X--Asp--Phe--NH.sub.2 in which X represents leucine or methionine, and process for preparing them by reacting tert.butyl-protected heptapeptides with glutaric acid anhydride and subsequently splitting off the protective groups with the aid of trifluoroacetic acid.