1-Phenyl-2,2,4,4-C.sub.1 -C.sub.2 alkyl-3-[4-(phenyl or pyridyl)-piperazino]-cyclobutanols-(1)

US3931185A · kind A · utility

Assignee

• Boehringer Ingelheim GmbH · DE

Inventors

• Manfred Kleemann · Bergheim, DE
• Joachim Kahling · Biberach, DE
• Gerhart Griss · Zell am Harmersbach, DE
• Rudolf Hurnaus · Großenhain, DE

Key dates

• Filing date: Nov 6, 1973
• Grant date: Jan 6, 1976
• Expiry date: Nov 6, 1993

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K31/495
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This invention relates to cyclobutane derivatives having the formula ##SPC1## Wherein R.sub.1 to R.sub.3, which may be the same or different, represent hydrogen atoms, halogen atoms, hydroxy, trifluoromethyl, benzyloxy, acyloxy groups, alkyl groups with 1 to 6 carbon atoms, alkoxy groups with 1 to 3 carbon atoms, phenyl, cyclohexyl, or 2 of the radicals R.sub.1 to R.sub.3 together represents a methylenedioxy group, PA1 R.sub.4 represents a hydrogen atom or an alkyl group with 1 or 2 carbon atoms, PA1 R.sub.5 represents a hydrogen atom or an alkyl group with 1 to 3 carbon atoms and PA1 R.sub.6 represents a phenyl group, which may be mono- or disubstituted by halogen atoms, trifluoromethyl, hydroxy, nitro, amino, benzyloxy, acyloxy groups, alkyl groups with 1 to 3 carbon atoms, alkoxy groups with 1 to 3 carbon atoms or alkylthio groups with 1 to 3 carbon atoms; or a pyridyl group, optionally substituted by a halogen atom, a hydroxy, nitro, amino, benzyloxy, acyloxy, carboxy group, a carbalkoxy group with 1 to 3 carbon atoms in the alkoxy, an alkyl group with 1 to 3 carbon atoms or an alkoxy group with 1 to 3 carbon atoms; To salts thereof with physiologically compatible inorganic or …