13-Sulfa-prostaglandins

US3932487A · kind A · utility

Assignee

• Merck Patent GmbH · DE

Inventors

• Josef Kramer
• Hans-Eckart Radunz · Darmstadt, DE
• Dieter Orth · Darmstadt, DE
• Manfred Baumgarth
• Jurgen Harting · Darmstadt, DE

Key dates

• Filing date: Nov 15, 1973
• Grant date: Jan 13, 1976
• Expiry date: Nov 15, 1993

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2601/08
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Sulfides of the general formula ##SPC1## Wherein R.sub.1 is H or alkyl, R.sub.2 is =O, (H,OH), or (H,lower-acyloxy), R.sub.3 is H, OH or lower-acyloxy, R.sub.4 is alkyl or alkyl substituted by F, OH, lower-acyloxy, phenyl or p-tolyl, and A is alkylene which can be mono- or polysubstituted by F, and the physiologically acceptable salts thereof, possess, in addition to a blood-pressure-lowering activity, prostaglandin-type and antiprostaglandin-type effects.