Benzomorphanes

US3936463A · kind A · utility

Assignee

• BAYER HEALTHCARE LLC · DE

Inventors

• Otto Behner · Wuppertal, DE
• Ulrich Horlein · Wuppertal, DE
• Friedrich Hoffmeister
• Hans Werner Schubert

Key dates

• Filing date: Dec 3, 1973
• Grant date: Feb 3, 1976
• Expiry date: Dec 3, 1993

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D221/26
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Benzomorphanes of the formula: ##SPC1## Wherein PA1 R is cyclopropylmethyl or cyclobutylmethyl; PA1 R.sup.1 and R.sup.2 are the same or different and each is lower alkyl; PA1 R.sup.3 is hydrogen; a straight, branched or cyclic, saturated, partially unsaturated or unsaturated aliphatic hydrocarbon unsubstituted or substituted by 1 or more substituents selected from the group consisting of lower alkoxy, lower alkoxycarbonyl, lower alkylmercapto, aryloxy, arylmercapto, arylamino, and an acid amide; an unsubstituted or substituted aromatic moiety; an unsubstituted or substituted 5-, 6- or 7-membered heterocyclic ring; lower alkylamino; di(lower alkyl)amino; arylamino; lower alkyl-arylamino; lower alkoxy; urethane; an acid amide; lower alkoxycarbonylamino; or lower alkoxycarbonyl-lower alkylamino; and PA1 A is a bivalent, straight- or branched-chain, saturated, partially unsaturated or unsaturated hydrocarbon of 2 to 10 carbon atoms, unsubstituted or substituted by phenyl or by phenyl substituted by at least 1 substituent selected from the group consisting of lower alkyl, lower alkoxy, nitro, amino and halogen, And pharmaceutically acceptable nontoxic salts thereof, are useful as analge…