Plasma substitute including artificial starch and method for the preparation thereof
US3937821A · kind A · utility
Assignee
Inventors
Key dates
| Filing date | Nov 19, 1973 |
| Grant date | Feb 10, 1976 |
| Priority date | — |
| Expiry date | Nov 19, 1993 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC08B31/12
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
A process for preparing a pyrogen-free plasma substitute consisting of treating hydroxyethyl starch having a DS of 0.5 - 0.6 (preferably 0.55) and an intrinsic viscosity of 0.28 - 0.30 with an acid to lower the molecular weight; adjusting it to the desired hydroxyethyl starch having a DS of 0.55 and an intrinsic viscosity of 0.08- 0.14; adding a depyrogen reagent, such as Raney-nickel to it, if necessary, obtaining an isotonic aqueous solution containing 6% of hydroxyethyl starch and other various salts, preferably, adding sodium chloride (0.5%), potassium chloride (0.03%), calcium chloride dihydrate (0.02%), sodium lactate (0.224%), and glucose (1%)(W/V%) to 6% hydroxyethyl starch solution; and then adjusting the pH of the obtained iostonic aqueous solution to 6.2 .+-. 0.5.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.