Patent · US Expired

Orally active bronchospasmolytic compounds and their preparation

US3937838A · kind A · utility

20Cited by
4References
7Claims
0Family size

Assignee

Inventors

Key dates

Filing dateJun 21, 1973
Grant dateFeb 10, 1976
Priority date—
Expiry dateJun 21, 1993

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC07C45/63
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Novel compounds are disclosed having useful activity as bronchodilators of improved longevity of action and reduced incidence of side effects. These compounds are described by the formula: ##EQU1## wherein R.sub.1 is a member of the class consisting of tertiary butyl and cyclobutyl, and R.sub.2 is a hydrogen or 2 to 5 carbon atom acyl radical, and pharmaceutically acceptable salts thereof. The activity of these compounds is compared to previously known bronchodilators such as 1-(3', 5'-dihydroxyphenyl)-2-(isopropylamino)-ethanol, having the common name orciprenaline, and 1-(3', 4'-dihydroxyphenyl-2-isoproplyamino-ethanol, having the common name isoprenaline.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.